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F2RL3 antibody (Coagulation Factor II (Thrombin) Receptor-Like 3) (AA 18-83)

Details for Product anti-F2RL3 Antibody No. ABIN396605, Supplier: Login to see New
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Synonyms F2RL3, F2, PAR4, AA408040, Lkb1, Par-4, R75140, mLKB1
AA 18-83
(13), (13), (10), (8), (7), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(105), (43), (41), (3), (2), (1), (1), (1), (1)
(91), (13), (1)
Clonality (Clone)
Monoclonal ()
This F2RL3 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB)
(59), (37), (27), (22), (19), (8), (6), (3), (3), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5F4
Isotype IgG1 kappa
Specificity F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F2RL3 (F2RL3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41133 DA
Gene ID 12406
NCBI Accession NP_003941
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-F2RL3 antibody (Coagulation Factor II (Thrombin) Receptor-Like 3) (AA 18-83) (ABIN396605) Detection limit for recombinant GST tagged F2RL3 is approximately 0.03 ng/mL as a cap...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ramstrom, ONeill, Dunne et al.: "Annexin V binding to platelets is agonist, time and temperature dependent." in: Platelets, Vol. 21, Issue 4, pp. 289-96, 2010 (PubMed).

Chen, Tsou, Tsai et al.: "Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 737-45, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Megyeri, Makó, Beinrohr et al.: "Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 5, pp. 3409-16, 2009 (PubMed).

Catalog No. ABIN396605
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