Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3) antibody

Details for Product No. ABIN396605
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms PAR4, F2RL3, F2
Reactivity
Human
(96), (59), (59), (14), (13), (13), (12), (1), (1)
Host
Mouse
(88), (10), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(52), (40), (30), (27), (18), (10), (9), (8), (3), (3), (1)
Pubmed 5 references available
Catalog no. ABIN396605
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5F4
Isotype IgG1 kappa
Specificity F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F2RL3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41133 DA
Gene ID 12406
UniProt NP_003941
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3) antibody Detection limit for recombinant GST tagged F2RL3 is approximately 0.03 ng/mL as a capture antibody.
Background publications Megyeri, Makó, Beinrohr et al.: "Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 5, pp. 3409-16, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Chen, Tsou, Tsai et al.: "Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 737-45, 2010 (PubMed).

Ramstrom, ONeill, Dunne et al.: "Annexin V binding to platelets is agonist, time and temperature dependent." in: Platelets, Vol. 21, Issue 4, pp. 289-96, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (88), (10), (1)
Reactivities (96), (59), (59), (14), (13), (13), (12), (1), (1)
Applications (52), (40), (30), (27), (18), (10), (9), (8), (3), (3), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Epitopes (12), (7), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
back to top