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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, eta Polypeptide (YWHAH) (AA 71-170) antibody

Details for Product No. ABIN396657, Supplier: Login to see
Antigen
  • ywha1
  • 14-3-3e
  • YWHAH
  • YWHA1
Epitope
AA 71-170
12
4
3
3
3
2
2
1
1
Reactivity
Human
60
23
22
9
8
6
6
2
2
1
Host
Mouse
54
12
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
Application
ELISA, Western Blotting (WB)
61
30
17
14
9
5
4
1
1
1
Supplier
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Immunogen YWHAH (AAH03047, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6A12
Isotype IgG2a kappa
Specificity YWHAH (AAH03047, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name YWHAH (YWHAH Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 28219 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, eta Polypeptide (YWHAH) (AA 71-170) antibody (ABIN396657) Detection limit for recombinant GST tagged YWHAH is approximately 0.1 ng/mL as a capt...
Background publications Liu, Tian, Li et al.: "The expression of seven 14-3-3 isoforms in human meningioma." in: Brain research, Vol. 1336, pp. 98-102, 2010 (PubMed).

Margariti, Zampetaki, Xiao et al.: "Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin." in: Circulation research, Vol. 106, Issue 7, pp. 1202-11, 2010 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Mangin, Receveur, Wurtz et al.: "Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets." in: Journal of thrombosis and haemostasis : JTH, Vol. 7, Issue 9, pp. 1550-5, 2009 (PubMed).

Brummer, Larance, Herrera Abreu et al.: "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein." in: The EMBO journal, Vol. 27, Issue 17, pp. 2305-16, 2009 (PubMed).