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Details for Product No. ABIN396657

tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, eta Polypeptide (YWHAH) antibody

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Antigen
Synonyms YWHA1, 14-3-3e, ywha1, YWHAH
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396657
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen YWHAH (AAH03047, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6A12
Isotype IgG2a kappa
Specificity YWHAH (AAH03047, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name YWHAH
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 28219 DA
Gene ID 12406
Research Area Cell Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brummer, Larance, Herrera Abreu et al.: "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein." in: The EMBO journal, Vol. 27, Issue 17, pp. 2305-16, 2009 (PubMed).

Mangin, Receveur, Wurtz et al.: "Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets." in: Journal of thrombosis and haemostasis : JTH, Vol. 7, Issue 9, pp. 1550-5, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Margariti, Zampetaki, Xiao et al.: "Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin." in: Circulation research, Vol. 106, Issue 7, pp. 1202-11, 2010 (PubMed).

Liu, Tian, Li et al.: "The expression of seven 14-3-3 isoforms in human meningioma." in: Brain research, Vol. 1336, pp. 98-102, 2010 (PubMed).

Alternatives for antigen "tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, eta Polypeptide (YWHAH)", type "Antibodies"
Hosts (27), (6)
Reactivities (29), (16), (15), (6), (5), (5), (4), (1), (1)
Applications (33), (11), (10), (8), (5), (2), (1), (1)
Epitopes (8), (4), (1), (1)
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