Variable Charge, X-Linked 3A (VCX3A) (AA 2-101) antibody

Details for Product No. ABIN396659
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Antigen
Synonyms VCX-8r, VCX-A, VCX3, VCX8R, VCXA
Epitope
AA 2-101
(10), (9), (3), (1)
Reactivity
Human
(15)
Host
Mouse
(11), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(15), (9), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396659
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Immunogen VCX3A (NP_057463, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6A3
Isotype IgG2a kappa
Specificity VCX3A (NP_057463, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VCX3A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20020 DA
Gene ID 12406
UniProt NP_057463
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number, different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Variable Charge, X-Linked 3A (VCX3A) (AA 2-101) antibody Western Blot analysis of VCX3A expression in transfected 293T cell line by VCX3A monoclonal antibody (M01), clone 6A3. Lane 1: VCX3A transfected lysate(17.8 KDa). Lane 2: Non-transfected lysate.
Background publications Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Jiao, Wang, Kiledjian: "Identification of an mRNA-decapping regulator implicated in X-linked mental retardation." in: Molecular cell, Vol. 24, Issue 5, pp. 713-22, 2006 (PubMed).

Cuevas-Covarrubias, González-Huerta: "Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis." in: The British journal of dermatology, Vol. 158, Issue 3, pp. 483-6, 2008 (PubMed).

Jiao, Chen, Chen et al.: "Modulation of neuritogenesis by a protein implicated in X-linked mental retardation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 40, pp. 12419-27, 2009 (PubMed).

Validation Images
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