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Details for Product No. ABIN396659

Variable Charge, X-Linked 3A (VCX3A) antibody

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Antigen
Synonyms VCX-8r, VCX-A, VCX3, VCX8R, VCXA
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396659
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen VCX3A (NP_057463, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6A3
Isotype IgG2a kappa
Specificity VCX3A (NP_057463, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VCX3A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20020 DA
Gene ID 12406
UniProt NP_057463
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number, different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Jiao, Wang, Kiledjian: "Identification of an mRNA-decapping regulator implicated in X-linked mental retardation." in: Molecular cell, Vol. 24, Issue 5, pp. 713-22, 2006 (PubMed).

Cuevas-Covarrubias, González-Huerta: "Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis." in: The British journal of dermatology, Vol. 158, Issue 3, pp. 483-6, 2008 (PubMed).

Jiao, Chen, Chen et al.: "Modulation of neuritogenesis by a protein implicated in X-linked mental retardation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 40, pp. 12419-27, 2009 (PubMed).

Alternatives for antigen "Variable Charge, X-Linked 3A (VCX3A)", type "Antibodies"
Hosts (5), (4)
Reactivities (9)
Applications (9), (3), (1), (1)
Epitopes (5), (3), (3)
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