Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN396674

Neighbor of BRCA1 Gene 1 (NBR1) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms Ca125, RGD1311421, 1A1-3B, M17S2, mKIAA0049, fa99f08, wu:fa99f08, MGC69008, NBR1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396674
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B11
Isotype IgG1 kappa
Specificity NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NBR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 107432 DA
Gene ID 12406
UniProt NP_005890
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kirkin, Lamark, Sou et al.: "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." in: Molecular cell, Vol. 33, Issue 4, pp. 505-16, 2009 (PubMed).

Kirkin, Lamark, Johansen et al.: "NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets." in: Autophagy, Vol. 5, Issue 5, pp. 732-3, 2009 (PubMed).

Waters, Marchbank, Solomon et al.: "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover." in: FEBS letters, Vol. 583, Issue 12, pp. 1846-52, 2009 (PubMed).

Mardakheh, Yekezare, Machesky et al.: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Alternatives for antigen "Neighbor of BRCA1 Gene 1 (NBR1)", type "Antibodies"
Hosts (6), (2)
Reactivities (7), (4), (2)
Applications (8), (4), (3)
Epitopes (2), (1)
Beacon