Neighbor of BRCA1 Gene 1 (NBR1) antibody

Details for Product No. ABIN396674
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Synonyms Ca125, RGD1311421, 1A1-3B, M17S2, mKIAA0049, fa99f08, wu:fa99f08, MGC69008, NBR1
(8), (5), (3)
(7), (2)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(9), (4), (3)
Pubmed 5 references available
Catalog no. ABIN396674
Quantity 0.1 mg
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Immunogen NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B11
Isotype IgG1 kappa
Specificity NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NBR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 107432 DA
Gene ID 12406
UniProt NP_005890
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody NBR1 monoclonal antibody (M01), clone 6B11. Western Blot analysis of NBR1 expression in PC-12. Detection limit for recombinant GST tagged NBR1 is approximately 0.1 ng/mL as a capture antibody.
anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody (2) anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody (Image 2)
Background publications Kirkin, Lamark, Sou et al.: "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." in: Molecular cell, Vol. 33, Issue 4, pp. 505-16, 2009 (PubMed).

Kirkin, Lamark, Johansen et al.: "NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets." in: Autophagy, Vol. 5, Issue 5, pp. 732-3, 2009 (PubMed).

Waters, Marchbank, Solomon et al.: "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover." in: FEBS letters, Vol. 583, Issue 12, pp. 1846-52, 2009 (PubMed).

Mardakheh, Yekezare, Machesky et al.: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Hosts (7), (2)
Reactivities (8), (5), (3)
Applications (9), (4), (3)
Epitopes (2)
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