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S100A6 antibody (S100 Calcium Binding Protein A6) (Met10)

Details for Product anti-S100A6 Antibody No. ABIN396682, Supplier: Log in to see
Antigen
  • S100A6
  • 2A9
  • 5B10
  • CABP
  • CACY
  • PRA
  • CALCYCLIN
  • Cacy
Epitope
Met10
23
18
5
3
3
2
2
1
1
1
1
1
1
Reactivity
Human
102
45
39
8
4
4
4
4
Host
Mouse
79
36
8
3
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This S100A6 antibody is un-conjugated
12
8
3
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
85
76
37
26
18
12
7
7
5
4
1
1
Supplier
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Immunogen S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B5
Isotype IgG1 kappa
Specificity S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A6 (S100A6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10180 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-S100A6 antibody (S100 Calcium Binding Protein A6) (Met10) (ABIN396682) Immunofluorescence of monoclonal antibody to S100A6 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-S100A6 antibody (S100 Calcium Binding Protein A6) (Met10) (ABIN396682) anti-S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody (Image 2)
Background publications van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Wei, Hoover, Ross et al.: "Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients." in: PLoS ONE, Vol. 4, Issue 10, pp. e7670, 2009 (PubMed).

Zimmermann, Biniossek, Maurer et al.: "Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction." in: Proteomics, Vol. 9, Issue 22, pp. 5175-87, 2009 (PubMed).

Nedjadi, Kitteringham, Campbell et al.: "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility." in: British journal of cancer, Vol. 101, Issue 7, pp. 1145-54, 2009 (PubMed).

Ishii, Suzuki, Satomi et al.: "Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression." in: Pathology international, Vol. 59, Issue 9, pp. 623-30, 2009 (PubMed).