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S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody

Details for Product No. ABIN396682
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Antigen
Synonyms S100A6, 2A9, 5B10, CABP, CACY, PRA, CALCYCLIN, Cacy
Epitope
Met10
(7), (6), (5), (3), (2), (2), (1)
Reactivity
Human
(67), (37), (35), (14), (13), (3), (2), (2), (2)
Host
Mouse
(47), (27), (3), (1), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(58), (39), (25), (23), (20), (17), (12), (11), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396682
450.00 $
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Immunogen S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6B5
Isotype IgG1 kappa
Specificity S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10180 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody Immunofluorescence of monoclonal antibody to S100A6 on HeLa cell (antibody concentration 10 µg/mL). S100A6 monoclonal antibody (M10), clone 6B5 Western Blot analysis of S100A6 expression in HeLa.
anti-S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody (2) anti-S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody (Image 2)
Background publications Ishii, Suzuki, Satomi et al.: "Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression." in: Pathology international, Vol. 59, Issue 9, pp. 623-30, 2009 (PubMed).

Nedjadi, Kitteringham, Campbell et al.: "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility." in: British journal of cancer, Vol. 101, Issue 7, pp. 1145-54, 2009 (PubMed).

Zimmermann, Biniossek, Maurer et al.: "Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction." in: Proteomics, Vol. 9, Issue 22, pp. 5175-87, 2009 (PubMed).

Wei, Hoover, Ross et al.: "Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients." in: PLoS ONE, Vol. 4, Issue 10, pp. e7670, 2009 (PubMed).

van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Validation Images
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