|+1 404 474 4654|
|+1 888 205 9894 (TF)|
S100 Calcium Binding Protein A6 (S100A6) (Met10) antibody
|Synonyms||2A9, PRA, 5B10, CABP, CACY, S100A6|
Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Quantity||0.1mg (1 mg/ml)|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: 2A9, 5B10, CABP, CACY, PRAS100 calcium binding protein A6 (calcyclin)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||S100A6 (AAH01431, 1 a.a. ~ 91 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||10180 DA|
Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Ishii, Suzuki, Satomi et al.: "Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression." in: Pathology international, Vol. 59, Issue 9, pp. 623-30, 2009 (PubMed).
Nedjadi, Kitteringham, Campbell et al.: "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility." in: British journal of cancer, Vol. 101, Issue 7, pp. 1145-54, 2009 (PubMed).
Zimmermann, Biniossek, Maurer et al.: "Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction." in: Proteomics, Vol. 9, Issue 22, pp. 5175-87, 2009 (PubMed).
Wei, Hoover, Ross et al.: "Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients." in: PLoS ONE, Vol. 4, Issue 10, pp. e7670, 2009 (PubMed).
van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).
|Hosts||Rabbit (36), Mouse (11), Guinea Pig (4), Chicken (1)|
|Reactivities||Human (44), Mouse (Murine) (26), Rat (Rattus) (26), Rabbit (4), Cat (Feline) (2), Cow (Bovine) (2), Dog (Canine) (2), Horse (Equine) (2)|
|Applications||Western Blotting (WB) (34), ELISA (31), Immunofluorescence (IF) (22), Immunohistochemistry (IHC) (18), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunocytochemistry (ICC) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Biotin (5), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (2), AA 1-90 (1), Met16 (1)|