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Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) (AA 1-101) antibody

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AA 1-101
(5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(52), (7), (1)
(30), (20), (2)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(48), (35), (24), (23), (16), (12), (11), (2)
Pubmed 6 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen TACC3 (NP_006333, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6C4
Isotype IgG3 kappa
Specificity TACC3 (NP_006333, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TACC3 (TACC3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 90360 DA
Gene ID 12406
NCBI Accession NP_006333
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The function of this gene has not yet been determined, however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) (AA 1-101) antibody (ABIN396697) TACC3 monoclonal antibody (M02), clone 6C4 Western Blot analysis of TACC3 expression ...
Immunohistochemistry (IHC) image for anti-Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) (AA 1-101) antibody (ABIN396697) anti-Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) (AA 1-101) antibody (Image 2)
Product cited in: Nahm, Kim, Lee et al.: "Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression ..." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015 (PubMed).

Background publications Lin, Hu, Shih: "Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability." in: The Journal of cell biology, Vol. 189, Issue 7, pp. 1097-105, 2010 (PubMed).

Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).

Kiemeney, Sulem, Besenbacher et al.: "A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer." in: Nature genetics, Vol. 42, Issue 5, pp. 415-9, 2010 (PubMed).

Couch, Wang, Bamlet et al.: "Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 251-7, 2010 (PubMed).

Jeng, Lin, Lin et al.: "Cdh1 controls the stability of TACC3." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 21, pp. 3529-36, 2009 (PubMed).

Catalog No. ABIN396697

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