Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) antibody

Antigen: Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3)

Synonyms: ERIC1, MGC117382, MGC133242

Clonality: Monoclonal (6C4)

Host: Mouse

Reactivity: Human

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396697

Additional Information

Alternative name: TACC3

Gene ID: 10460

UniProt: NP_006333

Immunogen: TACC3 (NP_006333, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG3 kappa

Clone: 6C4

Description: Other names: ERIC1, MGC117382, MGC133242 transforming, acidic coiled-coil containing protein 3

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TACC3 (NP_006333, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 90360 DA

Comments:

Background: The function of this gene has not yet been determined, however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Cell Structure

Restrictions: For Research Use only

Images

TACC3 monoclonal antibody (M02), clone 6C4 Western Blot analysis of TACC3 expression in Hela NE ( Cat # L013V3 ). Immunoperoxidase of monoclonal antibody to TACC3 ( Cat # AT4133a ) on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]

anti-Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) antibody (Image 2)

Publications

Product: Jeng, Lin, Lin et al.: "Cdh1 controls the stability of TACC3." in: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 21, pp. 3529-36, 2009 (PubMed).

Couch, Wang, Bamlet et al.: "Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 251-7, 2010 (PubMed).

Kiemeney, Sulem, Besenbacher et al.: "A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer." in: Nature genetics, Vol. 42, Issue 5, pp. 415-9, 2010 (PubMed).

Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).

Lin, Hu, Shih: "Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability." in: The Journal of cell biology, Vol. 189, Issue 7, pp. 1097-105, 2010 (PubMed).