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S100A6 antibody (S100 Calcium Binding Protein A6) (Met16)

Details for Product anti-S100A6 Antibody No. ABIN396706, Supplier: Log in to see
Antigen
  • S100A6
  • 2A9
  • 5B10
  • CABP
  • CACY
  • PRA
  • CALCYCLIN
  • Cacy
Epitope
Met16
23
18
5
3
3
2
2
1
1
1
1
1
1
Reactivity
Human
102
45
39
8
4
4
4
4
Host
Mouse
79
36
8
3
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This S100A6 antibody is un-conjugated
12
8
3
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
85
76
37
26
19
12
7
7
5
4
1
1
Supplier
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Immunogen S100A6 (NP_055439, 18 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6D1
Isotype IgG2a kappa
Specificity S100A6 (NP_055439, 18 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A6 (S100A6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10180 DA
Gene ID 12406
NCBI Accession NP_055439
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-S100A6 antibody (S100 Calcium Binding Protein A6) (Met16) (ABIN396706) Western Blot analysis of S100A6 expression in transfected 293T cell line by S100A6 mo...
Immunohistochemistry (IHC) image for anti-S100A6 antibody (S100 Calcium Binding Protein A6) (Met16) (ABIN396706) anti-S100 Calcium Binding Protein A6 (S100A6) (Met16) antibody (Image 2)
Background publications van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Wei, Hoover, Ross et al.: "Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients." in: PLoS ONE, Vol. 4, Issue 10, pp. e7670, 2009 (PubMed).

Zimmermann, Biniossek, Maurer et al.: "Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction." in: Proteomics, Vol. 9, Issue 22, pp. 5175-87, 2009 (PubMed).

Nedjadi, Kitteringham, Campbell et al.: "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility." in: British journal of cancer, Vol. 101, Issue 7, pp. 1145-54, 2009 (PubMed).

Ishii, Suzuki, Satomi et al.: "Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression." in: Pathology international, Vol. 59, Issue 9, pp. 623-30, 2009 (PubMed).