Microtubule-Actin Crosslinking Factor 1 (MACF1) antibody

Antigen: Microtubule-Actin Crosslinking Factor 1 (MACF1)

Synonyms: ACF7, MACF, OFC4, ABP620, FLJ45612, FLJ46776, KIAA0465, KIAA1251, Acf7, Aclp7, mACF7, R74989, mKIAA0465, MACF1, fc46g01, wu:fc46g01, si:rp71-45k5.7, acf7, macf, ofc4, abp620, DKFZp469K2016

Clonality: Monoclonal (6G7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN396755

Additional Information

Alternative name: MACF1

Gene ID: 23499

Immunogen: MACF1 (AAH07330, 1 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 6G7

Description: Other names: ABP620, ACF7, FLJ46776, KIAA0465, KIAA1251, MACF, OFC4 microtubule-actin crosslinking factor 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: MACF1 (AAH07330, 1 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 620418 DA

Comments:

Background: The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged MACF1 is approximately 1ng/ml as a capture antibody.

Publications

Product: Martins-de-Souza, Gattaz, Schmitt et al.: "Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation." in: BMC psychiatry, Vol. 9, pp. 17, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).