C1D Nuclear Receptor Corepressor (C1D) antibody

Antigen: C1D Nuclear Receptor Corepressor (C1D)

Synonyms: MGC131377, LRP1, SUNCOR, SUN-CoR, MGC12261, MGC14659, AI875855, 1110036E10Rik, C1D, MGC133553

Clonality: Monoclonal (6H2)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396763

Additional Information

Alternative name: C1D

Gene ID: 10438

Immunogen: C1D (AAH05235, 1 a.a. ~ 142 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 6H2

Description: Other names: MGC12261, MGC14659, SUNCOR nuclear DNA-binding protein

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: C1D (AAH05235, 1 a.a. ~ 142 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 16019 DA

Comments:

Background: The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to C1D (AT1333a) on HeLa cell . [antibody concentration 10 ug/ml] Western Blot analysis of C1D expression in transfected 293T cell line by C1D monoclonal antibody (M03), clone 6H2. Lane 1: C1D transfected lysate(16 KDa). Lane 2: Non-transfected lysate.

anti-C1D Nuclear Receptor Corepressor (C1D) antibody (Image 2)

Publications

Product: Schilders, van Dijk, Pruijn: "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing." in: Nucleic acids research, Vol. 35, Issue 8, pp. 2564-72, 2007 (PubMed).

Schilders, Egberts, Raijmakers et al.: "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome." in: Arthritis and rheumatism, Vol. 56, Issue 7, pp. 2449-54, 2007 (PubMed).

Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).