Arginine Vasopressin Receptor 1A (AVPR1A) antibody

Antigen: Arginine Vasopressin Receptor 1A (AVPR1A)

Synonyms: AVPR1, V1a, AVPR, V1aR, MGC108538, Avpr1, AVPR1A, MGC155312, VT4

Clonality: Monoclonal (7B8)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396775

Additional Information

Alternative name: AVPR1A

Gene ID: 552

UniProt: NP_000697

Immunogen: AVPR1A (NP_000697, 1 a.a. ~ 53 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 7B8

Description: Other names: AVPR1 arginine vasopressin receptor 1A

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: AVPR1A (NP_000697, 1 a.a. ~ 53 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 46800 DA

Comments:

Background: The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

Western Blot analysis of AVPR1A expression in transfected 293T cell line by AVPR1A monoclonal antibody (M07), clone 7B8. Lane 1: AVPR1A transfected lysate(46.8 KDa). Lane 2: Non-transfected lysate.

Publications

Product: Binder, Owens, Liu et al.: "Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response." in: Archives of general psychiatry, Vol. 67, Issue 4, pp. 369-79, 2010 (PubMed).

Yang, Cho, Yoo et al.: "Family-based association study of microsatellites in the 5' flanking region of AVPR1A with autism spectrum disorder in the Korean population." in: Psychiatry research, Vol. 178, Issue 1, pp. 199-201, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Yang, Cho, Yoo et al.: "Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders." in: Neuroscience letters, Vol. 479, Issue 3, pp. 197-200, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).