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Antizyme Inhibitor 1 antibody (AZIN1) (AA 339-448)

Details for Product anti-AZIN1 Antibody No. ABIN396802, Supplier: Log in to see
Antigen
  • AZIN1
  • azin1
  • oazin
  • wu:fj32d12
  • OAZIN
  • MGC81852
  • AZS
  • oaz1
  • azi
  • oaz
  • ODC-Az
  • MGC75770
  • AZ1
  • OAZ1
  • oaz1S
  • OAZI
  • ODC1L
  • 1700085L02Rik
  • AI414949
  • Oazi
  • Oazin
Epitope
AA 339-448
2
2
2
2
1
Reactivity
Human
18
7
7
Host
Mouse
12
6
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
17
10
8
3
2
Supplier
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Immunogen AZIN1 (NP_056962, 339 a.a. ~ 448 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8B9
Isotype IgG2a kappa
Specificity AZIN1 (NP_056962, 339 a.a. ~ 448 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AZIN1 (AZIN1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 49535 DA
Gene ID 12406
NCBI Accession NP_056962
Research Area Metabolism, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Antizyme Inhibitor 1 antibody (AZIN1) (AA 339-448) (ABIN396802) Detection limit for recombinant GST tagged AZIN1 is approximately 0.3 ng/mL as a capt...
Background publications Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: , Vol. 3, pp. 89, 2007 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Reuter, Medhurst, Waisfisz et al.: "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport." in: Experimental cell research, Vol. 289, Issue 2, pp. 211-21, 2003 (PubMed).

Imabayashi, Mori, Gojo et al.: "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis." in: Experimental cell research, Vol. 288, Issue 1, pp. 35-50, 2003 (PubMed).