Antizyme Inhibitor 1 (AZIN1) antibody

Antigen: Antizyme Inhibitor 1 (AZIN1)

Synonyms: Oazi, Oazin, AI414949, 1700085L02Rik, AZIN1, oazin, wu:fj32d12, OAZIN, MGC81852, MGC89611, MGC143073, DKFZp459G073, azin1, AZI, OAZ, MGC138338, AZ1, Oaz, AZ-1, ODC-Az, Antizyme, ODCAC, OAZI, ODC1L, MGC691, MGC3832, AZS, azi, oaz, MGC75770, OAZ1, oaz1, oaz1S

Clonality: Monoclonal (8B9)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396802

Additional Information

Alternative name: AZIN1

Gene ID: 51582

UniProt: NP_056962

Immunogen: AZIN1 (NP_056962, 339 a.a. ~ 448 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 8B9

Description: Other names: MGC3832, MGC691, OAZI, OAZIN, ODC1L antizyme inhibitor 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: AZIN1 (NP_056962, 339 a.a. ~ 448 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 49535 DA

Comments:

Background: Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.

Synonyms: Oazi, Oazin, AI414949, 1700085L02Rik, AZIN1, oazin, wu:fj32d12, OAZIN, MGC81852, MGC89611, MGC143073, DKFZp459G073, azin1, AZI, OAZ, MGC138338, AZ1, Oaz, AZ-1, ODC-Az, Antizyme, ODCAC, OAZI, ODC1L, MGC691, MGC3832, AZS, azi, oaz, MGC75770, OAZ1, oaz1, oaz1S

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged AZIN1 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Imabayashi, Mori, Gojo et al.: "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis." in: Experimental cell research, Vol. 288, Issue 1, pp. 35-50, 2003 (PubMed).

Reuter, Medhurst, Waisfisz et al.: "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport." in: Experimental cell research, Vol. 289, Issue 2, pp. 211-21, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).