Coagulation Factor XIII, A1 Polypeptide (F13A1) antibody

Details for Product No. ABIN396823
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Antigen
Synonyms F13a, F13A, AI462306, 1200014I03Rik, F13A1, f13a1, wu:fo83d04, zgc:153334
Reactivity
Human
(96), (2), (2)
Host
Mouse
(47), (33), (15), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (1), (1)
Application
ELISA
(49), (45), (42), (7), (6), (6), (6), (6), (5), (5), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN396823
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen F13A1 (AAH27963, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1
Isotype IgG IgA IgM Mix lambda
Specificity F13A1 (AAH27963, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F13A1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 83267 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Coagulation Factor XIII, A1 Polypeptide (F13A1) antibody Detection limit for recombinant GST tagged F13A1 is approximately 0.3 ng/mL as a capture antibody.
Background publications Antón, González-Conejero, Roldán et al.: "Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders." in: Annals of hematology, Vol. 89, Issue 11, pp. 1147-54, 2010 (PubMed).

Carreras-Torres, Athanasiadis, Via et al.: "Allele-allele interaction within the F13A1 gene: a risk factor for ischaemic heart disease in Spanish population." in: Thrombosis research, Vol. 126, Issue 3, pp. e241-5, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Hosts (47), (33), (15), (7)
Reactivities (96), (2), (2)
Applications (49), (45), (42), (7), (6), (6), (6), (6), (5), (5), (3), (2), (2), (1)
Conjugates (2), (1), (1)
Epitopes (5), (3), (2), (1), (1), (1), (1)
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