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Coagulation Factor XIII, A1 Polypeptide (F13A1) (AA 1-733) antibody

Details for Product No. ABIN396823, Supplier: Log in to see
Antigen
  • F13A1
  • f13a1
  • wu:fo83d04
  • zgc:153334
  • F13A
  • F13a
  • 1200014I03Rik
  • AI462306
Epitope
AA 1-733
10
10
7
5
4
4
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
150
13
10
1
1
1
1
Host
Mouse
62
58
19
18
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
3
2
1
1
1
Application
ELISA
83
69
38
28
18
11
8
7
7
7
7
6
6
3
2
1
1
1
Supplier
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Immunogen F13A1 (AAH27963, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1
Isotype IgG IgA IgM Mix lambda
Specificity F13A1 (AAH27963, 1 a.a. ~ 733 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F13A1 (F13A1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 83267 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Coagulation Factor XIII, A1 Polypeptide (F13A1) (AA 1-733) antibody (ABIN396823) Detection limit for recombinant GST tagged F13A1 is approximately 0.3 ng/mL as a capt...
Background publications Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Carreras-Torres, Athanasiadis, Via et al.: "Allele-allele interaction within the F13A1 gene: a risk factor for ischaemic heart disease in Spanish population." in: Thrombosis research, Vol. 126, Issue 3, pp. e241-5, 2010 (PubMed).

Antón, González-Conejero, Roldán et al.: "Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders." in: Annals of hematology, Vol. 89, Issue 11, pp. 1147-54, 2010 (PubMed).