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Legumain (LGMN) (AA 1-434) antibody

Details for Product No. ABIN396827
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Antigen
Synonyms
MGC64351, cb173, cb460, sb:cb173, zgc:76953, wu:fa98g05, wu:fj92g08, lgmn, MGC88980, DELTA VACUOLAR PROCESSING ENZYME, DELTAVPE, delta vacuolar processing enzyme, Prsc1, AEP, LGMN1, PRSC1, AI746452, A ... show more
MGC64351, cb173, cb460, sb:cb173, zgc:76953, wu:fa98g05, wu:fj92g08, lgmn, MGC88980, DELTA VACUOLAR PROCESSING ENZYME, DELTAVPE, delta vacuolar processing enzyme, Prsc1, AEP, LGMN1, PRSC1, AI746452, AU022324 show less
Epitope
AA 1-434
(9), (8), (5), (2), (2), (1), (1)
Reactivity
Human
(35), (12), (12), (12), (12)
Host
Mouse
(31), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(23), (10), (10), (5), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396827
450.00 $
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Immunogen LGMN (AAH03061, 1 a.a. ~ 434 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1
Isotype IgG1 kappa
Specificity LGMN (AAH03061, 1 a.a. ~ 434 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LGMN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 49411 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Legumain (LGMN) (AA 1-434) antibody Detection limit for recombinant GST tagged LGMN is approximately 0.1 ng/mL as a capture antibody.
Background publications Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Liu, Jang, Liu et al.: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, 2008 (PubMed).

Clerin, Shih, Deng et al.: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Validation Images
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