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Trefoil Factor 1 (TFF1) (AA 1-85) antibody

Details for Product No. ABIN396833, Supplier: Log in to see
Antigen
  • BCEI
  • bcei
  • Bcei
  • D21S21
  • d21s21
  • HP1.A
  • hp1.a
  • HPS2
  • hps2
  • p1
  • p1-a
  • pnr-2
  • pNR-2
  • Ps2
  • PS2
  • pS2
  • ps2
  • tff1
  • TFF1
  • xp1
  • xP1
  • xp1-L
Alternatives
anti-Human Trefoil Factor 1 antibody for Immunohistochemistry
Epitope
AA 1-85
133
76
12
8
5
5
3
2
2
2
1
1
1
Reactivity
Human
204
44
29
26
18
9
Host
Mouse
150
63
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
3
Application
ELISA, Western Blotting (WB)
127
108
95
45
45
31
30
30
28
1
1
1
1
1
Supplier
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Immunogen TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1
Isotype IgG1 kappa
Specificity TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TFF1 (TFF1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 9150 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Pathways EGFR Signaling Pathway
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Trefoil Factor 1 (TFF1) (AA 1-85) antibody (ABIN396833) Detection limit for recombinant GST tagged TFF1 is approximately 0.3 ng/mL as a captu...
Background publications Tosco, Monti, Fontanella, Montefusco, DAndrea, Ziaco, Baldantoni, Rio, Marzullo: "Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 11, pp. 1943-55, 2010 (PubMed).

Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Rinnert, Hinz, Buhtz, Reiher, Lessel, Hoffmann: "Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine." in: Cell and tissue research, Vol. 339, Issue 3, pp. 639-47, 2010 (PubMed).

Oguri, Kato, Yokoi, Yoshida, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Association of gene polymorphisms with chronic kidney disease in Japanese individuals." in: International journal of molecular medicine, Vol. 24, Issue 4, pp. 539-47, 2009 (PubMed).