Trefoil Factor 1 (TFF1) antibody

Antigen: Trefoil Factor 1 (TFF1)

Synonyms: pS2, BCEI, HPS2, HP1.A, pNR-2, D21S21, PS2, Bcei, p1, ps2, xP1, bcei, hps2, p1-a, hp1.a, pnr-2, d21s21, TFF1, xp1

Clonality: Monoclonal (M1)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396833

Additional Information

Alternative name: TFF1

Gene ID: 7031

Immunogen: TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: M1

Description: Other names: BCEI, D21S21, HP1.A, HPS2, pNR2, pS2 trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 9150 DA

Comments:

Background: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged TFF1 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Yoshida, Kato, Yokoi et al.: "Association of gene polymorphisms with chronic kidney disease in Japanese individuals." in: International journal of molecular medicine, Vol. 24, Issue 4, pp. 539-47, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Rinnert, Hinz, Buhtz et al.: "Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine." in: Cell and tissue research, Vol. 339, Issue 3, pp. 639-47, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Tosco, Monti, Fontanella et al.: "Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 11, pp. 1943-55, 2010 (PubMed).