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CD1a Molecule (CD1A) (AA 1-312) antibody

Details for Product No. ABIN396835, Supplier: Log in to see
Antigen
  • CD1A
  • CD1.1
  • CD1.2
  • CD1A2
  • CD1
  • FCB6
  • HTA1
  • R4
  • T6
  • CD1B
  • AI747460
  • Cd1a
  • Cd1d
  • Ly-38
  • CD1b molecule
  • CD1 antigen
  • CD1a molecule
  • CD1d1 antigen
  • CD1B
  • CD1.1
  • CD1A
  • Cd1d1
Epitope
AA 1-312
21
15
12
12
11
10
5
4
4
3
2
2
2
2
1
1
1
Reactivity
Human
509
38
29
15
14
8
6
4
Host
Mouse
396
130
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
42
37
27
15
15
12
11
11
10
10
10
9
9
9
9
7
7
7
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
374
172
169
160
135
120
107
107
38
15
11
5
3
3
3
1
1
1
Options
Supplier
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Immunogen CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1-2-1B5
Isotype IgG2b kappa
Specificity CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CD1A (CD1A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37172 DA
Gene ID 12406
Research Area Cell Structure, Cell Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CD1a Molecule (CD1A) (AA 1-312) antibody (ABIN396835) CD1A monoclonal antibody (M01), clone M1-2-1B5 Western Blot analysis of CD1A expressi...
Background publications Zeissig, Dougan, Barral, Junker, Chen, Kaser, Ho, Mandel, McIntyre, Kennedy, Painter, Veerapen, Besra, Cerundolo, Yue, Beladi, Behar, Chen, Gumperz, Breckpot, Raper, Baer, Exley, Hegele, Cuchel et al.: "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. ..." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2889-99, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Cernadas, Cavallari, Watts, Mori, De Libero, Brenner: "Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 3, pp. 1235-41, 2010 (PubMed).

Valencia, Hernández-López, Martínez, Hidalgo, Zapata, Vicente, Varas, Sacedón: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, 2010 (PubMed).

Young, Kasmar, Moraski, Cheng, Walz, Hu, Xu, Endres, Uzieblo, Zajonc, Costello, Miller, Moody: "Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 25087-96, 2009 (PubMed).