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CD1a Molecule (CD1A) (AA 1-312) antibody

Details for Product No. ABIN396835
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Antigen
Synonyms CD1A, CD1.1, CD1.2, CD1A2, CD1, FCB6, HTA1, R4, T6, CD1B, AI747460, Cd1a, Cd1d, Ly-38
Epitope
AA 1-312
(22), (8), (7), (3), (2), (2), (1)
Reactivity
Human
(220), (25), (24), (10), (10), (4)
Host
Mouse
(173), (77)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(24), (21), (16), (7), (7), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(115), (58), (49), (48), (30), (30), (27), (19), (19), (6), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396835
450.00 $
Plus shipping costs $45.00

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Immunogen CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1-2-1B5
Isotype IgG2b kappa
Specificity CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CD1A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37172 DA
Gene ID 12406
Research Area Cell Structure, Cell Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-CD1a Molecule (CD1A) (AA 1-312) antibody CD1A monoclonal antibody (M01), clone M1-2-1B5 Western Blot analysis of CD1A expression in K-562.
Background publications Young, Kasmar, Moraski et al.: "Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 25087-96, 2009 (PubMed).

Valencia, Hernández-López, Martínez et al.: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, 2010 (PubMed).

Cernadas, Cavallari, Watts et al.: "Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 3, pp. 1235-41, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Zeissig, Dougan, Barral et al.: "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2889-99, 2010 (PubMed).

Validation Images
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