CD1a Molecule (CD1A) antibody

Antigen: CD1a Molecule (CD1A)

Synonyms: R4, T6, CD1, FCB6, HTA1, CD1A, CD1.1, CD1.2, CD1A2

Clonality: Monoclonal (M1-2-1B5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396835

Additional Information

Alternative name: CD1A

Gene ID: 909

Immunogen: CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: M1-2-1B5

Description: Other names: CD1 CD1A antigen, a polypeptide

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 37172 DA

Comments:

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Cell Cycle

Restrictions: For Research Use only

Images

CD1A monoclonal antibody (M01), clone M1-2-1B5 Western Blot analysis of CD1A expression in K-562 ( Cat # L009V1 ).

Publications

Product: Young, Kasmar, Moraski et al.: "Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 25087-96, 2009 (PubMed).

Valencia, Hernández-López, Martínez et al.: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, 2010 (PubMed).

Cernadas, Cavallari, Watts et al.: "Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 3, pp. 1235-41, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Zeissig, Dougan, Barral et al.: "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2889-99, 2010 (PubMed).