|+1 404 474 4654|
|+1 888 205 9894 (TF)|
CD1a Molecule (CD1A) antibody
|Synonyms||R4, T6, CD1, FCB6, HTA1, CD1A, CD1.1, CD1.2, CD1A2|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CD1 CD1A antigen, a polypeptide|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||CD1A (AAH31645, 1 a.a. ~ 312 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||37172 DA|
Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure, Cell Cycle|
|Restrictions||For Research Use only|
|CD1A monoclonal antibody (M01), clone M1-2-1B5 Western Blot analysis of CD1A expression in K-562 ( Cat # L009V1 ).|
Young, Kasmar, Moraski et al.: "Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 25087-96, 2009 (PubMed).
Valencia, Hernández-López, Martínez et al.: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, 2010 (PubMed).
Cernadas, Cavallari, Watts et al.: "Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 3, pp. 1235-41, 2010 (PubMed).
Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).
Zeissig, Dougan, Barral et al.: "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2889-99, 2010 (PubMed).