Acid Phosphatase 2, Lysosomal (ACP2) (AA 1-424) antibody

Details for Product No. ABIN396836
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Antigen
Synonyms ACP2, Acp-2, LAP
Epitope
AA 1-424
(4), (2), (2), (1), (1), (1)
Reactivity
Human
(14), (7), (4), (1), (1)
Host
Mouse
(11), (4)
Clonality (Clone)
Monoclonal ()
Application
Immunofluorescence (IF), Western Blotting (WB)
(15), (6), (6), (5), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396836
450.00 $
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Immunogen ACP2 (AAH03160, 1 a.a. ~ 424 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1-4A12
Isotype IgG2b lambda
Specificity ACP2 (AAH03160, 1 a.a. ~ 424 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACP2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48344 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Acid Phosphatase 2, Lysosomal (ACP2) (AA 1-424) antibody Immunofluorescence of monoclonal antibody to ACP2 on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of ACP2 expression in transfected 293T cell line by ACP2 monoclonal antibody (M01), clone M1-4A12. Lane 1: ACP2 transfected lysate(48.3 KDa). Lane 2: Non-transfected lysate.
anti-Acid Phosphatase 2, Lysosomal (ACP2) (AA 1-424) antibody (2) anti-Acid Phosphatase 2, Lysosomal (ACP2) (AA 1-424) antibody (Image 2)
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Melquist, Craig, Huentelman et al.: "Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms." in: American journal of human genetics, Vol. 80, Issue 4, pp. 769-78, 2007 (PubMed).

Wang, McDonnell, Hebbring et al.: "Polymorphisms in mitochondrial genes and prostate cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3558-66, 2008 (PubMed).

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