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Details for Product No. ABIN396842

Barrier To Autointegration Factor 1 (BANF1) antibody

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Synonyms BAF, BCRP1, D14S1460, NGPS, Baf, Bcrp1, L2bp1, L2bp1/Baf, C78287, CG7380, Dmel\\CG7380, anon-WO0172774.178, dBAF, BANF1, DKFZp468C097, baf, bcrp1, fa01c01, wu:fa01c01, zgc:77767
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396842
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen BANF1 (AAH05942, 1 a.a. ~ 90 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M2
Isotype IgG2a kappa
Specificity BANF1 (AAH05942, 1 a.a. ~ 90 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BANF1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10059 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Background: The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Li, Craigie: "Virology: HIV goes nuclear." in: Nature, Vol. 441, Issue 7093, pp. 581-2, 2006 (PubMed).

Haraguchi, Koujin, Osakada et al.: "Nuclear localization of barrier-to-autointegration factor is correlated with progression of S phase in human cells." in: Journal of cell science, Vol. 120, Issue Pt 12, pp. 1967-77, 2007 (PubMed).

Wiebe, Traktman: "Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication." in: Cell host & microbe, Vol. 1, Issue 3, pp. 187-97, 2007 (PubMed).

Haraguchi, Kojidani, Koujin et al.: "Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly." in: Journal of cell science, Vol. 121, Issue Pt 15, pp. 2540-54, 2008 (PubMed).

Montes de Oca, Shoemaker, Gucek et al.: "Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners." in: PLoS ONE, Vol. 4, Issue 9, pp. e7050, 2009 (PubMed).

Alternatives for antigen "Barrier To Autointegration Factor 1 (BANF1)", type "Antibodies"
Hosts (44), (13)
Reactivities (57), (32), (22), (12), (12)
Applications (46), (30), (25), (22), (10), (4), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (6), (5), (4), (2), (2), (1), (1), (1)