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Fatty Acid Synthase antibody (FASN) (AA 1-440)

Details for Product anti-FASN Antibody No. ABIN396850, Supplier: Log in to see
Antigen
  • FASN
  • fj34h12
  • wu:fj34h12
  • Cgl0836
  • BcDNA:GH07626
  • BcDNA:gh07626
  • DM_7295848
  • Dmel\\CG3523
  • FAS
  • Fatty acid synthase
  • anon-EST:Posey235
  • anon-EST:Posey43
  • anon-WO0138581.1
  • dFAS
  • fas
  • OA-519
  • SDR27X1
  • A630082H08Rik
  • fatty acid synthase
  • fatty acid synthase Fas
  • Fatty acid synthase Fas
  • Fatty Acid SyNthase
  • fatty-acid synthase
  • fatty-acid synthase II
  • fatty-acid synthase fas
  • CG3523 gene product from transcript CG3523-RA
  • fas
  • FASN
  • fasn
  • fasn-1
  • NCgl0802
  • fasB
  • MT2600
  • TBMG_01448
  • CG3523
  • Fasn
Alternatives
anti-Human Fatty Acid Synthase antibody for Western Blotting
Epitope
AA 1-440
15
15
14
14
12
12
8
5
5
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
134
71
46
7
5
4
3
3
2
2
2
2
2
2
2
Host
Mouse
101
41
7
Clonality (Clone)
Monoclonal ()
Conjugate
This Fatty Acid Synthase antibody is un-conjugated
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
114
45
38
36
28
20
15
13
5
5
2
2
1
1
1
Options
Supplier
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Immunogen FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone S1
Isotype IgG1 kappa
Specificity FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FASN (FASN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 273400 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Pathways AMPK Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Fatty Acid Synthase antibody (FASN) (AA 1-440) (ABIN396850) Western Blot analysis of FASN expression in transfected 293T cell line by FASN monocl...
Background publications Nguyen, Ma, Chavarro, Freedman, Lis, Fedele, Fiore, Qiu, Fiorentino, Finn, Penney, Eisenstein, Schumacher, Mucci, Stampfer, Giovannucci, Loda: "Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 25, pp. 3958-64, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Zeng, Biernacka, Holly, Jarrett, Morrison, Morgan, Winters, Foulstone, Shield, Perks: "Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase." in: Endocrine-related cancer, Vol. 17, Issue 2, pp. 539-51, 2010 (PubMed).

Fernandez-Real, Menendez, Moreno-Navarrete, Blüher, Vazquez-Martin, Vázquez, Ortega, Diéguez, Frühbeck, Ricart, Vidal-Puig: "Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance." in: Diabetes, Vol. 59, Issue 6, pp. 1506-11, 2010 (PubMed).