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Fatty Acid Synthase antibody (FASN) (AA 1-440)

Details for Product anti-FASN Antibody No. ABIN396850, Supplier: Log in to see
Antigen
  • FASN
  • fj34h12
  • wu:fj34h12
  • Cgl0836
  • BcDNA:GH07626
  • BcDNA:gh07626
  • DM_7295848
  • Dmel\\CG3523
  • FAS
  • Fatty acid synthase
  • anon-EST:Posey235
  • anon-EST:Posey43
  • anon-WO0138581.1
  • dFAS
  • fas
  • OA-519
  • SDR27X1
  • A630082H08Rik
Alternatives
anti-Human Fatty Acid Synthase antibody for Western Blotting
Epitope
AA 1-440
15
14
13
12
8
8
7
5
5
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
112
46
30
6
3
2
1
1
Host
Mouse
93
28
7
Clonality (Clone)
Monoclonal ()
Conjugate
This Fatty Acid Synthase antibody is un-conjugated
3
3
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
91
41
31
25
19
14
11
10
5
4
2
2
1
1
1
Supplier
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Immunogen FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone S1
Isotype IgG1 kappa
Specificity FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FASN (FASN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 273400 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Pathways AMPK Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Fatty Acid Synthase antibody (FASN) (AA 1-440) (ABIN396850) Western Blot analysis of FASN expression in transfected 293T cell line by FASN monocl...
Background publications Nguyen, Ma, Chavarro et al.: "Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 25, pp. 3958-64, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Zeng, Biernacka, Holly et al.: "Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase." in: Endocrine-related cancer, Vol. 17, Issue 2, pp. 539-51, 2010 (PubMed).

Fernandez-Real, Menendez, Moreno-Navarrete et al.: "Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance." in: Diabetes, Vol. 59, Issue 6, pp. 1506-11, 2010 (PubMed).