Fatty Acid Synthase (FASN) (AA 1-440) antibody

Details for Product No. ABIN396850
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Antigen
Synonyms
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, ... show more
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, A630082H08Rik show less
Epitope
AA 1-440
(8), (8), (6), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (21), (14), (4), (2), (1), (1)
Host
Mouse
(52), (18), (4)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(67), (25), (25), (22), (14), (14), (12), (8), (5), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396850
450.00 $
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Immunogen FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone S1
Isotype IgG1 kappa
Specificity FASN (AAH07909, 1 a.a. ~ 440 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FASN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 273400 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Fatty Acid Synthase (FASN) (AA 1-440) antibody Western Blot analysis of FASN expression in transfected 293T cell line by FASN monoclonal antibody (M03), clone S1. Lane 1: FASN transfected lysate(48.3 KDa). Lane 2: Non-transfected lysate.
Background publications Fernandez-Real, Menendez, Moreno-Navarrete et al.: "Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance." in: Diabetes, Vol. 59, Issue 6, pp. 1506-11, 2010 (PubMed).

Zeng, Biernacka, Holly et al.: "Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase." in: Endocrine-related cancer, Vol. 17, Issue 2, pp. 539-51, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Nguyen, Ma, Chavarro et al.: "Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 25, pp. 3958-64, 2010 (PubMed).

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