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HIF1A antibody (AA 400-550)
HIF1A
Reactivity: Human, Protozoa
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HIF1A Antibody
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Target
See all HIF1A Antibodies
HIF1A
(Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
Binding Specificity
All epitopes for HIF1A antibodies
AA 400-550
Reactivity
All reactivities for HIF1A antibodies
Human, Protozoa
Host
All hosts for HIF1A antibodies
Rabbit
Clonality
All clonalities for HIF1A antibodies
Polyclonal
Conjugate
All conjugates for HIF1A antibodies
This HIF1A antibody is un-conjugated
Application
All applications for HIF1A antibodies
Western Blotting (WB)
Cross-Reactivity
Human, Primate
Purification
affinity purified
Immunogen
Genomic sequence made to an internal portion of the human protein (within AA 400-550). [Swiss-Prot# Q16665].
Isotype
IgG
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Discover our top product HIF1A Primary Antibody
Alternatives
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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 341-450) antibody
HIF1A
Reactivity: Human, Mouse, Rat, Rabbit
WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilutions should be determined experimentally by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Storage
-20 °C
Target Details for HIF1A
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Target
HIF1A
(Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
Alternative Name
HIF-1 alpha (HIF1A Products )
Synonyms
hif1a antibody, AA959795 antibody, HIF1alpha antibody, MOP1 antibody, bHLHe78 antibody, HIF-1A antibody, HIF-1alpha antibody, HIF1 antibody, HIF1-ALPHA antibody, PASD8 antibody, HIF1-alpha antibody, hif-1a antibody, hypoxia inducible factor 1 alpha antibody, hypoxia inducible factor 1, alpha subunit antibody, hypoxia inducible factor 1 alpha subunit antibody, HIF (Hypoxia Inducible Factor) homologa antibody, hif-1a antibody, Hif1a antibody, HIF1A antibody, hif1a antibody, hif-1 antibody
Background
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. Itis a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF hydroxylases provide insight into hypoxic cell responses, which may be used to help isolate therapeutic targets.
UniProt
Q16665
Pathways
Positive Regulation of Peptide Hormone Secretion , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Cellular Response to Molecule of Bacterial Origin , Carbohydrate Homeostasis , Transition Metal Ion Homeostasis , Tube Formation , Regulation of Carbohydrate Metabolic Process , Signaling Events mediated by VEGFR1 and VEGFR2 , VEGFR1 Specific Signals , Warburg Effect
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