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CD40 antibody

CD40 Reactivity: Human, Monkey FACS, IHC (p) Host: Mouse Monoclonal HB14 unconjugated
Catalog No. ABIN400699
  • Target See all CD40 Antibodies
    CD40
    Reactivity
    • 188
    • 97
    • 20
    • 20
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Monkey
    Host
    • 103
    • 100
    • 43
    • 3
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 156
    • 89
    • 5
    Monoclonal
    Conjugate
    • 119
    • 22
    • 20
    • 20
    • 12
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD40 antibody is un-conjugated
    Application
    • 145
    • 92
    • 62
    • 50
    • 30
    • 28
    • 19
    • 18
    • 17
    • 14
    • 13
    • 13
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    Recognizes TNFRSF5/CD40.
    Cross-Reactivity (Details)
    Species reactivity (expected):Monkey.
    Species reactivity (tested):Human.
    Characteristics
    Synonyms: TNFRSF5, CDw40, Bp50, Tumor necrosis factor receptor superfamily member 5, B-cellsurface antigen CD40, CD40L receptor
    Purification
    Affinity Chromatography
    Immunogen
    Full length protein (Human).
    Clone
    HB14
    Isotype
    IgG1
    Top Product
    Discover our top product CD40 Primary Antibody
  • Application Notes
    Flow Cytometry: 0.5 μg/IE6 cells. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.2, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    CD40
    Alternative Name
    CD40 (CD40 Products)
    Synonyms
    Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
    Background
    CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.Synonyms: B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5, Tumor necrosis factor receptor superfamily member 5
    Gene ID
    958
    UniProt
    P25942
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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