CXCR2 antibody

Catalog No. ABIN400744

Product Details anti-CXCR2 Antibody

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCR2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognizes Interleukin 8 Receptor B (CXCR2/IL8RB).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: CXCR2, CXCR-2, GRO/MGSA receptor, IL-8 receptor type 2, CDw128b, IL8 receptor beta

Purification: Protein G Chromatography.

Immunogen: L1. 2 cells expressing Human Interleukin-8 Receptor type B (IL8RB).

Clone: 6D499

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry. Immunohistochemistry on Paraffin Sections: 2.5-5.0 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS without preservatives.

Preservative: Without preservative

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (Add 40-50% Glycerol) at -20 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Alternative Name: CD182 / IL8RB (CXCR2 Products)

Synonyms: CD182 antibody, CDw128b antibody, CMKAR2 antibody, IL8R2 antibody, IL8RA antibody, IL8RB antibody, CXC-R2 antibody, CXCR-2 antibody, CD128 antibody, CDw128 antibody, Cmkar2 antibody, Gpcr16 antibody, IL-8Rh antibody, IL-8rb antibody, Il8rb antibody, mIL-8RH antibody, C-X-C motif chemokine receptor 2 antibody, chemokine (C-X-C motif) receptor 2 antibody, Cxcr2 antibody, CXCR2 antibody

Background: CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.Synonyms: CDw128b, CXCR-2, CXCR2, GRO/MGSA receptor, IL-8 receptor type 2, IL8 receptor beta

Gene ID: 3579

UniProt: P25025

Pathways: cAMP Metabolic Process