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Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody

Details for Product No. ABIN400824, Supplier: Log in to see
Antigen
  • AV025995
  • bZ1P14.9
  • FSGS2
  • LLHWJM002
  • LLHWJM003
  • LLHWJM004
  • mtrp6
  • si:rp71-1p14.9
  • TRP-6
  • trp6
  • TRP6
  • trpc6
  • Trrp6
Epitope
C-Term
49
24
7
5
2
2
2
1
1
1
1
1
Reactivity
Chimpanzee, Human
103
56
32
5
5
4
3
3
2
2
2
1
Host
Mouse
76
42
8
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
105
64
35
16
12
5
5
4
3
1
1
Supplier
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6protein.
Clone 3F2-H10-F2
Isotype IgG1
Specificity This antibody is specific for Human TRPC6 protein.
Cross-Reactivity (Details) Species reactivity (expected):Chimpanzee.
Species reactivity (tested):Human.
Characteristics Synonyms: TRP-6, Short transient receptor potential channel 6
Purification Affinity Chromatography on Protein A
Alternative Name TRPC6 (TRPC6 Antibody Abstract)
Background TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or Gprotein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.Synonyms: Short transient receptor potential channel 6, TRP-6, Transient receptor protein 6
Gene ID 7225
UniProt Q9Y210
Research Area Signaling
Application Notes Immunohistochemistry: 2.5 μg/mL. Western Blot: 1/500- 1/2000. ELISA: 1/10000 - 1/50000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody (ABIN400824) anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody
Background publications Reiser, Polu, Möller, Kenlan, Altintas, Wei, Faul, Herbert, Villegas, Avila-Casado, McGee, Sugimoto, Brown, Kalluri, Mundel, Smith, Clapham, Pollak: "TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function." in: Nature genetics, Vol. 37, Issue 7, pp. 739-44, 2005 (PubMed).

DEsposito, Strazzullo, Cuccurese, Spalluto, Rocchi, DUrso, Ciccodicola: "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-->q22." in: Cytogenetics and cell genetics, Vol. 83, Issue 1-2, pp. 46-7, 1999 (PubMed).

Hofmann, Obukhov, Schaefer, Harteneck, Gudermann, Schultz: "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." in: Nature, Vol. 397, Issue 6716, pp. 259-63, 1999 (PubMed).

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