HAX1 antibody (N-Term)

Catalog No. ABIN400856

Product Details anti-HAX1 Antibody

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Binding Specificity: AA 1-279, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HAX1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes human HAX-1. Other species not tested.

Characteristics: Synonyms: HAX-1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-bindingprotein 1

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human HAX1 (1-279 aa) purified from E. coli

Clone: AT3C5

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot (1: 1000 - 1: 2000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to two weeks or (in aliquots) at -20 °C or -70 °Cfor longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for HAX1

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX1 (HAX1 Products)

Background: HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.Synonyms: HAX-1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1, HS1BP1

Gene ID: 10456

UniProt: O00165

Pathways: Regulation of Actin Filament Polymerization