Zinc Finger and BTB Domain Containing 7B (ZBTB7B) antibody

Details for Product No. ABIN400978
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Synonyms Thpok, Zfp67, c-Krox, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, ZBTB7B, zbtb7b, MGC130914
Human, Mouse (Murine), Rat (Rattus)
(32), (9), (5), (2), (2)
(18), (12), (3)
ELISA, Western Blotting (WB)
(30), (13), (10), (9), (8), (3), (2)
Pubmed 2 references available
Catalog no. ABIN400978
Quantity 0.1 mL
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Immunogen Synthetic peptide corresponding to an internal sequence of mouse cKrox protein
Isotype IgG
Specificity This antibody is directed against mouse cKrox.
Purification Serum
Alternative Name ZBTB7B
Background CKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.
Alternate names: T-helper-inducing POZ/Krueppel-like factor, Th-POK, Thpok, ZBT-15, ZBTB15, ZFP67, Zfp-67, Zinc finger and BTB domain-containing protein 15, Zinc finger and BTB domain-containing protein 7B, Zinc finger protein 67 homolog, c-Krox, cKrox
Gene ID 22724
NCBI Accession NP_033591.2
UniProt Q64321
Application Notes ELISA: 1: 2,500 - 1: 10,000. Western blot: 1: 500 - 1: 3,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 0.1 mL of deionized water.
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Storage 4 °C/-20 °C
Storage Comment Store vial at 2-8° C prior to opening. For extended storage, aliquot contents and freeze at -20° C or below.
Expiry Date 12 months
Supplier Images
anti-Zinc Finger and BTB Domain Containing 7B (ZBTB7B) antibody anti-Zinc Finger and BTB Domain Containing 7B (ZBTB7B) antibody
Background publications He, He, Dave et al.: "The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment." in: Nature, Vol. 433, Issue 7028, pp. 826-33, 2005 (PubMed).

Sun, Liu, Mercado et al.: "The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection." in: Nature immunology, Vol. 6, Issue 4, pp. 373-81, 2005 (PubMed).

Hosts (18), (12), (3)
Reactivities (32), (9), (5), (2), (2)
Applications (30), (13), (10), (9), (8), (3), (2)
Epitopes (4), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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