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Details for Product No. ABIN401041

beta-Site APP-Cleaving Enzyme 1 (BACE) antibody

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Antigen
Synonyms ASP2, BACE, HSPC104, C76936, Bace, zgc:77409, BACE1, MGC145931, bace2, MGC68881, MGC68482, BACE2
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN401041
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids near the carboxyl terminus of human BACE protein
Isotype IgG
Specificity This antibody is directed against BACE protein.
Purification DEAE ion exchange chromatography
Alternative Name BACE1
Background Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as the substrate for gamma-secretase to generate the 4 kDa amyloid- beta peptide, which is deposited in the brains of all sufferers of Alzheimer’s disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP.
Alternate names: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
Gene ID 23621
NCBI Accession NP_036236.1
UniProt P56817
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Application Notes Western Blot: 0.5-1 µg/ml. Immunohistochemistry: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Sinha, Anderson, Barbour et al.: "Purification and cloning of amyloid precursor protein beta-secretase from human brain." in: Nature, Vol. 402, Issue 6761, pp. 537-40, 1999 (PubMed).

Hussain, Powell, Howlett et al.: "Identification of a novel aspartic protease (Asp 2) as beta-secretase." in: Molecular and cellular neurosciences, Vol. 14, Issue 6, pp. 419-27, 2000 (PubMed).

Alternatives for antigen "beta-Site APP-Cleaving Enzyme 1 (BACE)", type "Antibodies"
Hosts (120), (7), (6)
Reactivities (126), (67), (46), (25), (25), (25), (21), (12), (1), (1), (1), (1), (1)
Applications (82), (51), (41), (20), (17), (14), (6), (4), (3), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (19), (17), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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