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Anaphase Promoting Complex Subunit 1 (ANAPC1) (AA 351-359), (pSer355) antibody

Details for Product No. ABIN401294, Supplier: Log in to see
Antigen
  • DDBDRAFT_0186456
  • DDBDRAFT_0234263
  • DDB_0186456
  • DDB_0234263
  • APC1
  • MCPR
  • TSG24
  • 2610021O03Rik
  • AI047775
  • AI853536
  • AW547281
  • Apc1
  • Mcpr
  • tsg24
  • EMBRYO DEFECTIVE 2771
  • MOP10.10
  • MOP10_10
  • anaphase promoting complex subunit 1
  • adenomatous polyposis coli
  • E3 ubiquitin ligase complex subunit
  • ANAPC1
  • CC1G_09696
  • anapc1
  • APC
  • Anapc1
  • EMB2771
Epitope
AA 351-359, pSer355
25
20
12
11
7
7
5
4
2
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Chimpanzee, Chicken, Human, Mouse (Murine), Rat (Rattus)
131
89
56
4
4
1
1
Host
Rabbit
131
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
62
54
44
40
30
25
6
4
3
2
2
1
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Immunogen Synthetic peptide corresponding to amino acids 351-359 of Human Apc1 protein
Isotype IgG
Specificity This antibody is specific for phosphorylated APC1 protein at the pS355 residue.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Bovine, Chimpanzee, Chicken.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name APC1 / ANAPC1 (ANAPC1 Antibody Abstract)
Background APC1 (also known as Anaphase promoting complex subunit 1, Cyclosome subunit 1, Protein Tsg24, Mitotic checkpoint regulator and ANAPC1) is 1 of at least 11 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.Synonyms: Anaphase-promoting complex subunit 1, Cyclosome subunit 1, MCPR, Mitotic checkpoint regulator, TSG24, Testis-specific gene 24 protein
Gene ID 64682
NCBI Accession NP_073153
UniProt Q9H1A4
Research Area Coagulation
Application Notes ELISA: 1/10,000 - 1/40,000. Western Blot: 1/200 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.55 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-Anaphase Promoting Complex Subunit 1 (ANAPC1) (AA 351-359), (pSer355) antibody (ABIN401294) anti-Anaphase Promoting Complex Subunit 1 (ANAPC1) (AA 351-359), (pSer355) antibody
Background publications Jörgensen, Gräslund, Betz, Ståhl, Larsson, Höög: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).