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Mre11 antibody (AA 68-706)

MRE11A Reactivity: Human, Rat, Mouse, Dog, Macaque WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401319
  • Target See all Mre11 (MRE11A) Antibodies
    Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
    Binding Specificity
    • 15
    • 15
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 68-706
    Reactivity
    • 74
    • 54
    • 41
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Macaque
    Host
    • 88
    • 5
    Rabbit
    Clonality
    • 78
    • 15
    Polyclonal
    Conjugate
    • 47
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This Mre11 antibody is un-conjugated
    Application
    • 73
    • 32
    • 26
    • 26
    • 19
    • 15
    • 14
    • 11
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against Mre11 protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Rat, Macaque, Human, Canine.
    Species reactivity (tested):Mouse.
    Purification
    Affinity Purified
    Immunogen
    Recombinant protein corres-ponding to amino acids 68-706 of mouse Mre11 protein
    Isotype
    IgG
    Top Product
    Discover our top product MRE11A Primary Antibody
  • Application Notes
    ELISA: 1/10000 - 1/50000. Western Blot: 1/500 - 1/2000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.05 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
    Alternative Name
    MRE11 (MRE11A Products)
    Synonyms
    wu:faa63d12 antibody, zgc:64018 antibody, Mre11 antibody, Mre11b antibody, ATLD antibody, HNGS1 antibody, MRE11 antibody, MRE11B antibody, MRE11 homolog A, double strand break repair nuclease antibody, MRE11 homolog, double strand break repair nuclease antibody, MRE11A homolog A, double strand break repair nuclease antibody, mre11a antibody, MRE11 antibody, Mre11a antibody
    Background
    Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1), which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses singlestrand endonuclease activity and doublestrand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Mre11 is a nuclear protein that is widely expressed and localizes to discrete nuclear foci after treatment with genotoxic agents (including irradiation). Alternative splice isoforms are recorded for this protein.Synonyms: Double-strand break repair protein MRE11A, HNGS1, MRE11 homolog 1, MRE11 meiotic recombination 11 homolog A, MRE11A
    Gene ID
    17535
    NCBI Accession
    NP_061206
    UniProt
    Q61216
    Pathways
    DNA Damage Repair
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