Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term) antibody

Details for Product No. ABIN401361
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Antigen
Synonyms IRAK-2, 6330415L08Rik, AI649099
Epitope
C-Term
(43), (11), (11), (7), (7), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(113), (35), (15)
Host
Rabbit
(113), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(117), (75), (28), (23), (18), (10), (9), (4)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN401361
368.50 $
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-2 protein
Isotype IgG
Specificity This antibody is directed against IRAK-2 protein.
Purification Affinity Purified
Alternative Name IRAK2
Background IRAK-2 (Interleukin-1 receptorassociated kinase 2). The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPSinduced NF-kappaB activation (2,3). Members of the IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
Alternate names: IRAK-2, Interleukin-1 receptor-associated kinase-like 2
Gene ID 3656
NCBI Accession NP_001561
UniProt O43187
Research Area Immunology, Innate Immunity, Cytokines, Receptors, Inflammation
Application Notes ELISA: 1/5000 - 1/20000. Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/300 - 1/600. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Zhang, Kirschning, Mancinelli et al.: "Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes." in: The Journal of biological chemistry, Vol. 274, Issue 12, pp. 7611-4, 1999 (PubMed).

Yang, Mark, Gurney et al.: "Signaling events induced by lipopolysaccharide-activated toll-like receptor 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 2, pp. 639-43, 1999 (PubMed).

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