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IRAK4 antibody (Interleukin-1 Receptor-Associated Kinase 4) (C-Term)

Details for Product anti-IRAK4 Antibody No. ABIN401362, Supplier: Login to see
Antigen
  • zgc:55553
  • IRAK4
  • ipd1
  • irak-4
  • ny-ran-64
  • ny-ren-64
  • ren64
  • irak4
  • IPD1
  • IRAK-4
  • NY-REN-64
  • REN64
  • 8430405M07Rik
  • 9330209D03Rik
Alternatives
anti-Human IRAK4 antibody for Immunoprecipitation
Epitope
C-Term
51
43
16
15
14
13
13
6
5
5
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
180
47
19
6
2
1
1
1
1
1
1
1
Host
Rabbit
138
28
26
Clonality
Polyclonal
Conjugate
This IRAK4 antibody is un-conjugated
9
8
7
6
5
5
4
3
3
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
145
85
26
23
19
11
10
6
4
4
3
2
2
2
1
Supplier
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-4 protein
Isotype IgG
Specificity This antibody is directed against IRAK-4 protein.
Purification Affinity chromatography
Alternative Name IRAK4 (IRAK4 Antibody Abstract)
Background IRAK-4 (Interleukin-1 receptor-associated kinase 4). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kappaB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
Gene ID 51135
NCBI Accession NP_001107654
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation
Pathways NF-kappaB Signaling, TLR Signaling
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/250 - 1/1,000. Immunohistochemistry: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-IRAK4 antibody (Interleukin-1 Receptor-Associated Kinase 4) (C-Term) (ABIN401362) anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (C-Term) antibody
 image for anti-IRAK4 antibody (Interleukin-1 Receptor-Associated Kinase 4) (C-Term) (ABIN401362) anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (C-Term) antibody (Image 2)
Background publications Picard, Puel, Bonnet et al.: "Pyogenic bacterial infections in humans with IRAK-4 deficiency. ..." in: Science (New York, N.Y.), Vol. 299, Issue 5615, pp. 2076-9, 2003 (PubMed).

Li, Strelow, Fontana et al.: "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5567-72, 2002 (PubMed).

Suzuki, Suzuki, Duncan et al.: "Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4." in: Nature, Vol. 416, Issue 6882, pp. 750-6, 2002 (PubMed).

Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Branlant, Krol, Ebel: "Characterization of the Escherichia coli 23S Ribosomal RNA region associated with ribosomal protein L1. Evidence for homologies with the 5'-end region of the L11 operon." in: Nucleic acids research, Vol. 8, Issue 23, pp. 5567-77, 1981 (PubMed).