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Details for Product No. ABIN401362

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (C-Term) antibody

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Antigen
Synonyms IPD1, IRAK-4, NY-REN-64, REN64, 8430405M07Rik, 9330209D03Rik, zgc:55553, IRAK4, ipd1, irak-4, ny-ran-64, ny-ren-64, ren64, irak4
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN401362
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-4 protein
Isotype IgG
Specificity This antibody is directed against IRAK-4 protein.
Purification Affinity chromatography
Alternative Name IRAK4
Background IRAK-4 (Interleukin-1 receptor-associated kinase 4). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll- like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappaB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kappaB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges (5,6). Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Alternate names: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
Gene ID 51135
NCBI Accession NP_001107654.1
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/250 - 1/1,000. Immunohistochemistry: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Branlant, Krol, Ebel: "Characterization of the Escherichia coli 23S Ribosomal RNA region associated with ribosomal protein L1. Evidence for homologies with the 5'-end region of the L11 operon." in: Nucleic acids research, Vol. 8, Issue 23, pp. 5567-77, 1981 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Suzuki, Suzuki, Duncan et al.: "Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4." in: Nature, Vol. 416, Issue 6882, pp. 750-6, 2002 (PubMed).

Li, Strelow, Fontana et al.: "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5567-72, 2002 (PubMed).

Picard, Puel, Bonnet et al.: "Pyogenic bacterial infections in humans with IRAK-4 deficiency." in: Science (New York, N.Y.), Vol. 299, Issue 5615, pp. 2076-9, 2003 (PubMed).

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)", type "Antibodies"
Hosts (73), (30), (11)
Reactivities (111), (40), (25), (24), (24), (24), (6), (1)
Applications (81), (42), (22), (20), (14), (9), (5), (4), (2), (2), (2), (1)
Conjugates (6), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (20), (17), (13), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1)
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