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Details for Product No. ABIN401363

Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

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Antigen
Synonyms ASRT5, IRAKM, IrakM, IRAK-M, AI563835, 4833428C18Rik, IRAK3, si:dkey-150i15.2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN401363
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-M protein
Isotype IgG
Specificity This antibody is directed against IRAK-M protein. No cross reactivity is noted against IRAK-1 or IRAK-2.
Purification Affinity chromatography
Alternative Name IRAK3
Background IRAK-M (Interleukin-1 receptor-associated kinase M). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induce cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). Through IL-1/Toll receptors, IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-kappaB (1,2), a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF- kappaB activation. Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
Alternate names: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995.1
UniProt Q9Y616
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/500 - 1/2,000. Immunohistochemistry: 1/300 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 3 (IRAK3)", type "Antibodies"
Hosts (53), (8), (8)
Reactivities (57), (25), (21), (1)
Applications (68), (34), (19), (15), (12), (6), (2), (2), (1)
Epitopes (28), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1)
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