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Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

Details for Product No. ABIN401363, Supplier: Log in to see
Antigen
  • IRAK3
  • si:dkey-150i15.2
  • ASRT5
  • IRAKM
  • IrakM
  • 4833428C18Rik
  • AI563835
  • IRAK-M
Alternatives
anti-Human Interleukin-1 Receptor-Associated Kinase 3 antibody for Western Blotting
Epitope
C-Term
56
18
15
8
6
6
5
5
5
4
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
104
49
30
1
Host
Rabbit
114
16
13
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
132
80
34
18
12
8
3
2
1
1
1
1
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-M protein
Isotype IgG
Specificity This antibody is directed against IRAK-M protein. No cross reactivity is noted against IRAK-1 or IRAK-2.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name IRAK3 (IRAK3 Antibody Abstract)
Background IRAK-M (Interleukin-1 receptor-associated kinase M). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induce cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). Through IL-1/Toll receptors, IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-κB (1,2), a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-kappaB activation. Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995
UniProt Q9Y616
Pathways TLR Signaling
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/500 - 1/2,000. Immunohistochemistry: 1/300 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (ABIN401363) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody
 image for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (ABIN401363) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (Image 2)
Background publications Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).