Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

Details for Product No. ABIN401363
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms IRAK3, si:dkey-150i15.2, ASRT5, IRAKM, IrakM, 4833428C18Rik, AI563835, IRAK-M
(56), (17), (15), (8), (7), (6), (5), (5), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(103), (46), (31), (1)
(111), (17), (12)
(6), (6), (5), (5), (5), (5)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(131), (78), (35), (15), (13), (7), (6), (3), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-M protein
Isotype IgG
Specificity This antibody is directed against IRAK-M protein. No cross reactivity is noted against IRAK-1 or IRAK-2.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name IRAK3 (IRAK3 Antibody Abstract)
Background IRAK-M (Interleukin-1 receptor-associated kinase M). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induce cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). Through IL-1/Toll receptors, IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-κB (1,2), a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-kappaB activation. Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995
UniProt Q9Y616
Pathways TLR Signaling
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/500 - 1/2,000. Immunohistochemistry: 1/300 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (ABIN401363) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody
Image no. 2 for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (ABIN401363) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (Image 2)
Background publications Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Catalog No. ABIN401363
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?