Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

Details for Product No. ABIN401363
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Antigen
Synonyms IRAK3, si:dkey-150i15.2, ASRT5, IRAKM, IrakM, 4833428C18Rik, AI563835, IRAK-M
Epitope
C-Term
(35), (8), (7), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(69), (30), (19), (1)
Host
Rabbit
(71), (9), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(85), (51), (21), (15), (14), (8), (4), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN401363
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human IRAK-M protein
Isotype IgG
Specificity This antibody is directed against IRAK-M protein. No cross reactivity is noted against IRAK-1 or IRAK-2.
Purification Affinity chromatography
Alternative Name IRAK3
Background IRAK-M (Interleukin-1 receptor-associated kinase M). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induce cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). Through IL-1/Toll receptors, IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-kappaB (1,2), a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF- kappaB activation. Members of the IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
Alternate names: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
NCBI Accession NP_001135995.1
UniProt Q9Y616
Application Notes ELISA: 1/5,000 - 1/20,000. Western Blot: 1/500 - 1/2,000. Immunohistochemistry: 1/300 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody
anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (2) anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody (Image 2)
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Wesche, Gao, Li et al.: "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19403-10, 1999 (PubMed).

Validation Images
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