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MYD88 antibody (Myeloid Differentiation Primary Response Gene (88)) (C-Term)

Details for Product anti-MYD88 Antibody No. ABIN401364, Supplier: Log in to see
Antigen
  • XMyD88
  • myd88d
  • MGC84928
  • CG2078
  • DMMYD88
  • DmMyD88
  • DmMyd88
  • Dmel\\CG2078
  • EP(2)2535
  • Kra
  • LD20892
  • MYD88
  • MyD88
  • Myd88F
  • dMyD88
  • dMyd88
  • kra
  • myd88
  • zgc:103541
  • GB12344
  • NV10640
  • irak-2
  • MYD88D
  • myeloid differentiation primary response gene (88)
  • CG2078 gene product from transcript CG2078-RB
  • myeloid differentiation primary response factor 88
  • myeloid differentiation primary response 88
  • myeloid differentiation primary response gene 88
  • MyD88 adaptor
  • myeloid differentiation factor 88
  • myeloid differentiation response protein 88
  • interleukin-1 receptor-associated kinase 2
  • myd88-b
  • Myd88
  • myd88
  • IRAK2
  • irak2
  • LOC100228175
  • MYD88
Alternatives
anti-Human MYD88 antibody for Western Blotting
Epitope
C-Term
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11
6
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2
1
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Reactivity
Human, Mouse (Murine)
245
131
66
11
6
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5
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4
4
2
1
1
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Host
Rabbit
160
68
19
8
Clonality
Polyclonal
Conjugate
This MYD88 antibody is un-conjugated
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3
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2
2
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2
2
2
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1
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Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
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38
13
9
4
3
2
2
2
1
1
1
Options
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human MyD88 protein
Isotype IgG
Specificity This antibody reacts to MYD88.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Purification Affinity Purified
Alternative Name MYD88 (MYD88 Antibody Abstract)
Background MyD88 (Myeloid differentiation primary response protein). The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and the dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaΒ activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), both members of the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to the bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. The MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
Gene ID 4615
NCBI Accession NP_001166037
UniProt Q99836
Pathways NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
Application Notes ELISA: 1/5000 - 1/20000. Western Blot: 1/500 - 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-MYD88 antibody (Myeloid Differentiation Primary Response Gene (88)) (C-Term) (ABIN401364) anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (C-Term) antibody
Background publications Kawai, Adachi, Ogawa, Takeda, Akira: "Unresponsiveness of MyD88-deficient mice to endotoxin." in: Immunity, Vol. 11, Issue 1, pp. 115-22, 1999 (PubMed).

Adachi, Kawai, Takeda, Matsumoto, Tsutsui, Sakagami, Nakanishi, Akira: "Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function." in: Immunity, Vol. 9, Issue 1, pp. 143-50, 1998 (PubMed).

Medzhitov, Preston-Hurlburt, Kopp, Stadlen, Chen, Ghosh, Janeway: "MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways." in: Molecular cell, Vol. 2, Issue 2, pp. 253-8, 1998 (PubMed).

Bonnert, Garka, Parnet, Sonoda, Testa, Sims: "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family." in: FEBS letters, Vol. 402, Issue 1, pp. 81-4, 1997 (PubMed).

Muzio, Ni, Feng, Dixit: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).