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MYD88 antibody (Myeloid Differentiation Primary Response Gene (88)) (C-Term)

Details for Product anti-MYD88 Antibody No. ABIN401364, Supplier: Log in to see
Antigen
  • XMyD88
  • myd88d
  • MGC84928
  • CG2078
  • DMMYD88
  • DmMyD88
  • DmMyd88
  • Dmel\\CG2078
  • EP(2)2535
  • Kra
  • LD20892
  • MYD88
  • MyD88
  • Myd88F
  • dMyD88
  • dMyd88
  • kra
  • myd88
  • zgc:103541
  • GB12344
  • NV10640
  • irak-2
  • MYD88D
Alternatives
anti-Human MYD88 antibody for Western Blotting
Epitope
C-Term
28
19
19
15
13
10
7
7
6
5
5
3
3
3
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
196
80
49
6
4
4
3
3
3
2
1
1
1
1
1
1
Host
Rabbit
166
28
15
Clonality
Polyclonal
Conjugate
This MYD88 antibody is un-conjugated
6
5
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
184
63
57
32
23
19
11
8
7
3
2
2
1
1
Supplier
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Immunogen Synthetic peptide corresponding to a region near the carboxy terminus of human MyD88 protein
Isotype IgG
Specificity This antibody reacts to MYD88.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Purification Affinity Purified
Alternative Name MYD88 (MYD88 Antibody Abstract)
Background MyD88 (Myeloid differentiation primary response protein). The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and the dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaΒ activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), both members of the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to the bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. The MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
Gene ID 4615
NCBI Accession NP_001166037
UniProt Q99836
Pathways NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway
Application Notes ELISA: 1/5000 - 1/20000. Western Blot: 1/500 - 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-MYD88 antibody (Myeloid Differentiation Primary Response Gene (88)) (C-Term) (ABIN401364) anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (C-Term) antibody
Background publications Kawai, Adachi, Ogawa et al.: "Unresponsiveness of MyD88-deficient mice to endotoxin." in: Immunity, Vol. 11, Issue 1, pp. 115-22, 1999 (PubMed).

Medzhitov, Preston-Hurlburt, Kopp et al.: "MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways." in: Molecular cell, Vol. 2, Issue 2, pp. 253-8, 1998 (PubMed).

Adachi, Kawai, Takeda et al.: "Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function." in: Immunity, Vol. 9, Issue 1, pp. 143-50, 1998 (PubMed).

Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Bonnert, Garka, Parnet et al.: "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family." in: FEBS letters, Vol. 402, Issue 1, pp. 81-4, 1997 (PubMed).