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GPX4 antibody (C-Term)

GPX4 Reactivity: Human, Mouse, Rat, Guinea Pig WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401375
  • Target See all GPX4 Antibodies
    GPX4 (Glutathione Peroxidase 4 (GPX4))
    Binding Specificity
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 46
    • 35
    • 30
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Guinea Pig
    Host
    • 46
    • 4
    • 1
    Rabbit
    Clonality
    • 37
    • 14
    Polyclonal
    Conjugate
    • 25
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPX4 antibody is un-conjugated
    Application
    • 34
    • 18
    • 18
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against GPx4 protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Rat, Guinea Pig, Human.
    Species reactivity (tested):Mouse.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse GPx4 protein
    Isotype
    IgG
    Top Product
    Discover our top product GPX4 Primary Antibody
  • Application Notes
    ELISA: 1/7,000 - 1/30,000. Western Blot: 1/500 - 1/3,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.15 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    GPX4 (Glutathione Peroxidase 4 (GPX4))
    Alternative Name
    Glutathione Peroxidase 4 / GPX4 (GPX4 Products)
    Synonyms
    GPx-4 antibody, GSHPx-4 antibody, MCSP antibody, PHGPx antibody, snGPx antibody, snPHGPx antibody, Phgpx antibody, gpx-4 antibody, snGpx antibody, cb563 antibody, cb691 antibody, PHGPxa antibody, sb:cb563 antibody, zgc:92253 antibody, wu:fb82e03 antibody, 1700027O09Rik antibody, mtPHGPx antibody, ATGPX4 antibody, F11L15.5 antibody, glutathione peroxidase 4 antibody, GP-GPx4 antibody, glutathione peroxidase 4 antibody, glutathione peroxidase 4a antibody, GPX4 antibody, Gpx4 antibody, gpx4a antibody
    Background
    Glutathione Peroxidase 4 (GPx4, also known as PHGPx) functions as an antioxidant and also plays a role in redox regulation, sexual maturation, inflammation, apoptosis, and differentiation. GPx4 was found to have an important role in preventing lipid peroxidation, and has been discussed primarily as the glutathione peroxidase protecting biomembranes against oxidative stress. GPx4 can react with free hydrogen peroxide as well as with a wide range of lipid hydroperoxides, including those derived from cholesterol and cholesteryl esters. GPx4 is the only GPx to use phospholipid hydroperoxides as substrates. It can also reduce thymine hydroperoxide. In contrast to GPx1 and GPx3, GPx4 can use a wide range of reducing substrates in addition to glutathione. GPx4 is expressed in high levels in testes, suggesting a role in male fertility. It has also been identified as an enzymatically inactive structural protein of the mitochondrial capsule of sperm.Synonyms: GPx-4, Phospholipid hydroperoxide glutathione peroxidase mitochondrial
    Gene ID
    2879
    NCBI Accession
    NP_001034936
    UniProt
    P36969
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