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Caspase 12 (CASP12) (N-Term) antibody

Details for Product No. ABIN401379, Supplier: Login to see
Antigen
  • Caspase-12
Epitope
N-Term
17
15
14
13
11
11
9
7
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
103
88
63
Host
Rabbit
129
11
11
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
130
60
50
38
15
12
12
6
6
6
2
1
Supplier
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Immunogen Synthetic peptide corresponding to amino acids near the amino terminus of mouse Caspase-12 protein
Isotype IgG
Specificity This antibody is directed against Caspase-12 protein.
Cross-Reactivity (Details) Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.
Purification Affinity Purified
Alternative Name Caspase-12 (CASP12 Antibody Abstract)
Background Three distinct signaling pathways lead to programmed cell death (apoptosis). Two of these are the death receptor and mitochondrion pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. Endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stressinduced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimers disease, including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).Synonyms: CASP-12, CASP12, Inactive caspase-12
Gene ID 12364
NCBI Accession NP_033938
UniProt O08736
Research Area Apoptosis/Necrosis
Pathways
Application Notes ELISA. Western Blot: 0.5-1 μg/mL. Immunohistochemistry: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-Caspase 12 (CASP12) (N-Term) antibody (ABIN401379) anti-Caspase 12 (CASP12) (N-Term) antibody
 image for anti-Caspase 12 (CASP12) (N-Term) antibody (ABIN401379) anti-Caspase 12 (CASP12) (N-Term) antibody (Image 2)
Background publications Mehmet: "Caspases find a new place to hide." in: Nature, Vol. 403, Issue 6765, pp. 29-30, 2000 (PubMed).

Van de Craen, Vandenabeele, Declercq et al.: "Characterization of seven murine caspase family members." in: FEBS letters, Vol. 403, Issue 1, pp. 61-9, 1997 (PubMed).