Caspase 12 (CASP12) (N-Term) antibody

Details for Product No. ABIN401379
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Antigen
Synonyms Caspase-12
Epitope
N-Term
(12), (10), (7), (7), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(86), (85), (68)
Host
Rabbit
(110), (9), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(99), (52), (39), (36), (20), (8), (8), (5), (5), (1), (1)
Pubmed 2 references available
Catalog no. ABIN401379
Quantity 0.1 mg
Price
368.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide corresponding to amino acids near the amino terminus of mouse Caspase-12 protein
Isotype IgG
Specificity This antibody is directed against Caspase-12 protein.
Purification Affinity Purified
Alternative Name Caspase-12
Background Three distinct signaling pathways lead to programmed cell death (apoptosis). Two of these are the death receptor and mitochondrion pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. Endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stressinduced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimers disease, including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).
Alternate names: CASP-12, CASP12, Inactive caspase-12
Gene ID 12364
NCBI Accession NP_033938.3
UniProt O08736
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: 0.5-1 µg/ml. Immunohistochemistry: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.02% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Caspase 12 (CASP12) (N-Term) antibody anti-Caspase 12 (CASP12) (N-Term) antibody
anti-Caspase 12 (CASP12) (N-Term) antibody (2) anti-Caspase 12 (CASP12) (N-Term) antibody (Image 2)
Background publications Van de Craen, Vandenabeele, Declercq et al.: "Characterization of seven murine caspase family members." in: FEBS letters, Vol. 403, Issue 1, pp. 61-9, 1997 (PubMed).

Mehmet: "Caspases find a new place to hide." in: Nature, Vol. 403, Issue 6765, pp. 29-30, 2000 (PubMed).

Hosts (110), (9), (3)
Reactivities (86), (85), (68)
Applications (99), (52), (39), (36), (20), (8), (8), (5), (5), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (10), (7), (7), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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