You are viewing an incomplete version of our website. Please click to reload the website as full version.

Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody

Details for Product No. ABIN401392, Supplier: Log in to see
Antigen
  • cb85
  • CR
  • CR-3
  • CR1
  • cr1
  • cr1a
  • CRGF
  • CRIPTO
  • cripto
  • Cripto-1
  • cripto-3
  • CRIPTO-3
  • CRIPTO3
  • frl-1
  • frl1
  • tdgf1
  • TDGF1
  • TDGF2
  • TDGF3
  • tdgf3
  • wu:fe01d04
  • xcr1
  • zgc:109829
Alternatives
anti-Human Teratocarcinoma-Derived Growth Factor 1 antibody for Western Blotting
Epitope
Internal Region
38
19
18
14
12
8
7
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
169
64
45
3
3
Host
Rabbit
130
34
13
10
Clonality
Polyclonal
Conjugate
Un-conjugated
18
18
17
7
7
7
6
5
5
5
4
4
4
4
4
3
3
3
3
3
2
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
87
62
57
44
28
22
17
17
5
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen Synthetic peptide corresponding to an internal sequence of human Cripto-1 protein
Isotype IgG
Specificity This antibody is specific for Cripto-1 protein. Expect cross-reactivity with Cripto-3 (TDGF2) based on very high levels of sequence conservation.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name TDGF1 / CRIPTO (TDGF1 Antibody Abstract)
Background Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.Synonyms: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1
Gene ID 6997
NCBI Accession NP_001167607
UniProt P13385
Pathways EGFR Signaling Pathway
Application Notes ELISA: 1/50,000 - 1/150,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.80 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody (ABIN401392) anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody
Background publications Bianco, Strizzi, Normanno, Khan, Salomon: "Cripto-1: an oncofetal gene with many faces." in: Current topics in developmental biology, Vol. 67, pp. 85-133, 2005 (PubMed).

Bianco, Strizzi, Ebert, Chang, Rehman, Normanno, Guedez, Salloum, Ginsburg, Sun, Khan, Hirota, Wallace-Jones, Wechselberger, Vonderhaar, Tosato, Stetler-Stevenson, Sanicola, Salomon: "Role of human cripto-1 in tumor angiogenesis." in: Journal of the National Cancer Institute, Vol. 97, Issue 2, pp. 132-41, 2005 (PubMed).