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Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody

Details for Product No. ABIN401392
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Antigen
Synonyms Cripto-1, cr1, cr1a, cripto, frl-1, frl1, tdgf1, xcr1, TDGF1, tdgf3, cripto-3, cb85, wu:fe01d04, zgc:109829, CR1, CR, CRGF, CRIPTO, CR-3, CRIPTO-3, CRIPTO3, TDGF2, TDGF3
Epitope
Internal Region
(12), (5), (4), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(88), (44), (41), (1), (1)
Host
Rabbit
(61), (33), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(56), (40), (26), (17), (15), (6), (4), (2), (1), (1)
Pubmed 2 references available
Quantity 25 µL
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Catalog No. ABIN401392
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Immunogen Synthetic peptide corresponding to an internal sequence of human Cripto-1 protein
Isotype IgG
Specificity This antibody is specific for Cripto-1 protein. Expect cross-reactivity with Cripto-3 (TDGF2) based on very high levels of sequence conservation.
Purification Affinity chromatography
Alternative Name TDGF1 / CRIPTO
Background Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over- expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.
Alternate names: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1
Gene ID 6997
NCBI Accession NP_001167607.1
UniProt P13385
Application Notes ELISA: 1/50,000 - 1/150,000. Western Blot: 1/500 - 1/2,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.80 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody
Background publications Bianco, Strizzi, Ebert et al.: "Role of human cripto-1 in tumor angiogenesis." in: Journal of the National Cancer Institute, Vol. 97, Issue 2, pp. 132-41, 2005 (PubMed).

Bianco, Strizzi, Normanno et al.: "Cripto-1: an oncofetal gene with many faces." in: Current topics in developmental biology, Vol. 67, pp. 85-133, 2005 (PubMed).

Validation Images
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