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THRA antibody (Isoform 1, N-Term)

THRA Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401406
  • Target See all THRA Antibodies
    THRA (Thyroid Hormone Receptor, alpha (THRA))
    Binding Specificity
    • 16
    • 11
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform 1, N-Term
    Reactivity
    • 66
    • 31
    • 30
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 43
    • 22
    • 1
    Rabbit
    Clonality
    • 46
    • 20
    Polyclonal
    Conjugate
    • 37
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This THRA antibody is un-conjugated
    Application
    • 60
    • 28
    • 24
    • 14
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts with Human THRA protein. A BLAST analysis was used to suggest cross-reactivity with THRA from Mouse, Human and Rat based on a 100 % homology with the immunizing sequence. Cross-reactivity with THRA from other sources has not been determined.
    Purification
    Immunoaffinity Chromatography
    Immunogen
    Synthetic peptide corresponding to a region near the amino terminus of Human THRA isoform 1 protein . Genename: THRA
    Isotype
    IgG
    Top Product
    Discover our top product THRA Primary Antibody
  • Application Notes
    ELISA: 1/650,000. Western Blot: 1/1,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.89 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    THRA (Thyroid Hormone Receptor, alpha (THRA))
    Alternative Name
    THRA / ERBA1 (THRA Products)
    Synonyms
    AR7 antibody, CHNG6 antibody, EAR7 antibody, ERB-T-1 antibody, ERBA antibody, ERBA1 antibody, NR1A1 antibody, THRA1 antibody, THRA2 antibody, c-ERBA-1 antibody, C-ERBA-ALPHA antibody, TRalpha antibody, c-erba antibody, erba antibody, nr1a1-A antibody, thra-A antibody, thra1 antibody, TR[a]1 antibody, nr1a1 antibody, thra antibody, thral antibody, tra antibody, tra1 antibody, wu:fb59g07 antibody, Thra1 antibody, 6430529J03Rik antibody, AW259572 antibody, Erba antibody, Nr1a1 antibody, Rvr antibody, T3R[a] antibody, T3Ralpha antibody, Thra2 antibody, C-ERBA ALPHA1 antibody, Thra antibody, fTHRalphaA antibody, nr1a1-a antibody, thyroid hormone receptor, alpha antibody, thyroid hormone receptor, alpha L homeolog antibody, thyroid hormone receptor alpha a antibody, thyroid hormone receptor alpha antibody, thyroid hormone receptor alpha-A antibody, THRA antibody, thra.L antibody, thraa antibody, Thra antibody, tr-alpha antibody, LOC109641414 antibody
    Background
    Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodothyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1
    Gene ID
    7067
    NCBI Accession
    NP_001177847
    UniProt
    P10827
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development
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