Nuclear Receptor Coactivator 3 (NCOA3) (Isoform A), (Internal Region) antibody

Details for Product No. ABIN401409
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Antigen
Synonyms
NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, 2010305B15Rik, AW321064, Actr, Aib1, Rac3, Src3, Tram-1, Tram1, p/Cip, pCip, actr, aib-1, aib ... show more
NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, 2010305B15Rik, AW321064, Actr, Aib1, Rac3, Src3, Tram-1, Tram1, p/Cip, pCip, actr, aib-1, aib1, cagh16, ctg26, kat13b, pcip, rac3, src-3, src3, tnrc14, tnrc16, tram-1, xSRC-3 show less
Epitope
Isoform A, Internal Region
(12), (9), (9), (9), (8), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey
(105), (19), (13), (13), (12), (12), (12), (12), (1)
Host
Rabbit
(69), (34), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(73), (28), (20), (19), (16), (10), (4), (3), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 25 µL
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Catalog No. ABIN401409
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Immunogen Synthetic peptide corresponding to an internal region of human NCOA3 isoform a protein
Isotype IgG
Specificity This antibody reacts with several isoforms of NCOA3 protein (a, b, d, e and f).
Purification Affinity chromatography
Alternative Name NCOA3
Background The NCOA3 (also known as nuclear receptor coactivator 3 isoform a) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions in a hormone-dependent fashion. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. NCOA3 probably acts via remodeling of chromatin and is involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). NCOA3 is also involved in the coactivation of the NF- kappa-B pathway via its interaction with the NFKB1 subunit. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. This antibody was raised against variant 1 which is the longer isoform (a). In addition, a polymorphic repeat region is found in the C-terminus of the protein.
Alternate names: ACTR, AIB-1, AIB1, Amplified in breast cancer 1 protein, BHLHE42, CBP-interacting protein, Class E basic helix-loop-helix protein 42, NCoA-3, Nuclear receptor coactivator 3, RAC-3, RAC3, Receptor-associated coactivator 3, SRC-3, Steroid receptor coactivator protein 3, TRAM-1, TRAM1, Thyroid hormone receptor activator molecule 1, pCIP
Gene ID 8202
NCBI Accession NP_001167559
UniProt Q9Y6Q9
Application Notes ELISA: 1/175000. Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.24 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Nuclear Receptor Coactivator 3 (NCOA3) (Isoform A), (Internal Region) antibody anti-Nuclear Receptor Coactivator 3 (NCOA3) (Isoform A), (Internal Region) antibody
Background publications Zheng, Wu, Smith et al.: "Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor." in: Molecular and cellular biology, Vol. 25, Issue 18, pp. 8273-84, 2005 (PubMed).

Feng, Yi, Wong et al.: "Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly." in: Molecular and cellular biology, Vol. 26, Issue 21, pp. 7846-57, 2006 (PubMed).

Hossain, Kuo, Saunders: "Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA." in: Molecular and cellular biology, Vol. 26, Issue 21, pp. 8191-201, 2006 (PubMed).

Rangel, Torabian, Shaikh et al.: "Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanoma." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 24, Issue 28, pp. 4565-9, 2006 (PubMed).

Naeem, Cheng, Zhao et al.: "The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation." in: Molecular and cellular biology, Vol. 27, Issue 1, pp. 120-34, 2006 (PubMed).

Li, Haque, Lu et al.: "Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 10, pp. 4065-70, 2007 (PubMed).

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