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TNKS2 antibody (AA 800-900)

TNKS2 Reactivity: Human, Mouse, Dog WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN401534
  • Target See all TNKS2 Antibodies
    TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))
    Binding Specificity
    • 8
    • 8
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 800-900
    Reactivity
    Human, Mouse, Dog
    Host
    • 26
    • 3
    • 1
    Goat
    Clonality
    • 29
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    This TNKS2 antibody is un-conjugated
    Application
    • 25
    • 20
    • 13
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects Tankyrase-2 (TANK2). No cross-reactivity expected with TANK1.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Canine (Dog).
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Affinity Chromatography using the immunizing peptide.
    Immunogen
    Fusion protein containing 73 aa from aa 800-900 region of the protein sequence according to NP_079511.1. Genename: TNKS2
    Top Product
    Discover our top product TNKS2 Primary Antibody
  • Application Notes
    Western blot: 0.5-1.5 μg/mL. In transfected HEK293 transiently expressing TANK2 a band of approx.127 kDa is observed. This band is not observed in the non-transfected HEK293. The calculated molecular size is127 kDa according to NP_079511.1. Full caption (see picture below): HEK293 overexpressing TANK2 (lane 4) and TANK1 (lane 2)and probed with ABIN401534 (mock transfection in first lane). Lane three is empty. Lowerpanel shows the same lysates probed for alpha-Actin to show protein levels. Primaryincubation (0.5 μg/mL) was overnight at 4 °C. Detected by chemiluminescence.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))
    Alternative Name
    Tankyrase-2 (TANK2) (TNKS2 Products)
    Synonyms
    ARTD6 antibody, PARP-5b antibody, PARP-5c antibody, PARP5B antibody, PARP5C antibody, TANK2 antibody, TNKL antibody, pART6 antibody, 5430432P15Rik antibody, AA517131 antibody, AI662480 antibody, TNKS-2 antibody, Tank2 antibody, tankyrase-2 antibody, TNKS2 antibody, tankyrase-1 antibody, tnks antibody, tnks.L antibody, tnks2 antibody, tankyrase 2 antibody, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog antibody, TNKS2 antibody, Tnks2 antibody, tnks2 antibody, tnks.S antibody
    Background
    Tankyrase 2 may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. It has PARP activity and can modify TRF1, and thereby contribute to the regulation of telomere length. Tankyrase 2 is highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Also highly expressed in fetal liver, heart and brain. Tankyrase 2 shares approximately 83 % sequence identity with Tankyrase 1.Synonyms: PARP5B, TNKL, TNKS-2, TNKS2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein
    Gene ID
    80351
    NCBI Accession
    NP_079511
    UniProt
    Q9H2K2
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